秦成峰教授和程根宏教授主要研究zika病毒的免疫机制,以及在zika病毒形成小脑症中的机制, 尤其是25羟基胆固醇作用寨卡病毒的潜在抑制剂。研究发现25羟基胆固醇通过阻断病毒进入 体内抑制ZIKV感染,并且用25羟基胆固醇对小鼠和恒河猴感染zika病毒时提供良好的保护作用, 减少病毒血症,同时还能抑制zika感染诱导小鼠小头畸形。这项研究使得用25羟基胆固醇可能作为天然抗病毒剂打击和预防zika感染及其并发症。池洪波教授研究T细胞活化过程中分子网络。
原始出处:
Yutao Wang, Xiaohan Ning, Pengfei Gao, Shuxian Wu, Mengyin Sha, Mengze Lv, Xiang Zhou, Juyi Gao, Run Fang, Guangxun Meng, Xiaodong Su, Zhengfan Jiang
Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection. Published online: March 14, 2017
Qiang Liu, Wei-Na Jin, Yaou Liu, Kaibin Shi, Haoran Sun, Fang Zhang, Chao Zhang, Rayna J. Gonzales, Kevin N. Sheth, Antonio La Cava, Fu-Dong Shi.
Brain Ischemia Suppresses Immunity in the Periphery and Brain via Different Neurogenic Innervations. Published online: March 14, 2017
Chunfeng Li, Yong-Qiang Deng, Shuo Wang, Feng Ma, Roghiyh Aliyari, Xing-Yao Huang, Na-Na Zhang, Momoko Watanabe, Hao-Long Dong, Ping Liu, Xiao-Feng Li, Qing Ye, Min Tian, Shuai Hong, Junwan Fan, Hui Zhao, Lili Li, Neda Vishlaghi, Jessie E. Buth, Connie Au, Ying Liu, Ning Lu, Peishuang Du, F. Xiao-Feng Qin, Bo Zhang, Danyang Gong, Xinghong Dai, Ren Sun, Bennett G. Novitch, Zhiheng Xu, Cheng-Feng Qin, Genhong Cheng.
25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model.Published online: March 14, 2017
Haiyan Tan, Kai Yang, Yuxin Li, Timothy I. Shaw, Yanyan Wang, Daniel Bastardo Blanco, Xusheng Wang, Ji-Hoon Cho, Hong Wang, Sherri Rankin, Cliff Guy, Junmin Peng, Hongbo Chi.
Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation.Published online: March 9, 2017