2012年ACOG临床指南132：抗磷脂抗体综合征（更新版）

该指南是美国妇产科医师学会对2011年1月的第118号临床指南的更新版！Antiphospholipid syndrome (APS) is an autoimmune disorder defined by the presence of characteristic clinical featuresand specified levels of circulating antiphospholipid antibodies (Box 1 and Box 2). Diagnosis requires that at leastone clinical and one laboratory criterion are met. Because approximately 70% of individuals with APS are female(1), it is reasonably prevalent among women of reproductive age. Antiphospholipid antibodies are a diverse group ofantibodies with specificity for binding to negatively charged phospholipids on cell surfaces. Despite the prevalenceand clinical significance of APS, there is controversy about the indications for and types of antiphospholipid tests thatshould be performed in order to diagnose the condition. Much of the debate results from a lack of well-designed andcontrolled studies on the diagnosis and management of APS. The purpose of this document is to evaluate the data fordiagnosis and treatment of APS.(Replaces Practice Bulletin Number 118, January 2011)