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[GetTopicListResponse(id=2263659, encodeId=6dd022636596c, content=<a href='/topic/show?id=21d33e36181' target=_blank style='color:#2F92EE;'>#参附注射液#</a>（SF）是由宋代中医古籍<a href='/topic/show?id=4ea712664813' target=_blank style='color:#2F92EE;'>#《严氏济生方》#</a>中记载的参附汤研制而成的中药复方制剂，由<a href='/topic/show?id=8a8624e210a' target=_blank style='color:#2F92EE;'>#人参#</a>和<a href='/topic/show?id=317e10535358' target=_blank style='color:#2F92EE;'>#附子#</a>两味中药组成。SF在中医中用于治疗<a href='/topic/show?id=a1901266498c' target=_blank style='color:#2F92EE;'>#厥证#</a>（与现代休克相对应），以其回阳、益气、救脱的作用而闻名。SF对脊髓、脑、小肠、肾脏和心脏等器官的失血性休克和I/R损伤引起的多器官<a href='/topic/show?id=8c323064e09' target=_blank style='color:#2F92EE;'>#再灌注损伤#</a>具有保护作用。肝<a href='/topic/show?id=1063e934733' target=_blank style='color:#2F92EE;'>#缺血再灌注损伤#</a>（HIRI）是外科手术后不可避免的挑战。肝脏中<a href='/topic/show?id=b79c6521eb7' target=_blank style='color:#2F92EE;'>#活性氧#</a>（ROS）的积累，沿着<a href='/topic/show?id=cef2e9344b2' target=_blank 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hrefUrl=https://www.medsci.cn/article/show_article.do?id=951c80619e22)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2170403, encodeId=335e21e0403a7, content=<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a> 喝点牛奶洗面奶, objectTitle=自噬, objectType=topic, longId=86109, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/097.jpg, objectUrl=null, replyNumber=0, likeNumber=119, createdTime=2023-11-23, rootId=0, userName=ms2000000147841561, userId=5bf26472850, projectId=1, avatar=, status=1, hasArticle=0, attachment=null, ipAttribution=河北省, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2164156, encodeId=020721641565c, content=<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a> 好记性不如烂笔头, objectTitle=自噬, objectType=topic, longId=86109, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/097.jpg, objectUrl=null, replyNumber=0, likeNumber=119, createdTime=2023-10-22, rootId=0, userName=ms2000000147841561, userId=5bf26472850, projectId=1, avatar=, status=1, hasArticle=0, attachment=null, ipAttribution=河北省, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2159705, encodeId=ae662159e0588, content=<a href='/topic/show?id=73a8988297a' target=_blank style='color:#2F92EE;'>#雷帕霉素#</a>治疗<a href='/topic/show?id=eb418106018' target=_blank style='color:#2F92EE;'>#肌萎缩侧索硬化症#</a>，雷帕霉素作为<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>诱导剂，原则上对所有的<a href='/topic/show?id=45719468e93' target=_blank style='color:#2F92EE;'>#退行性病变#</a>都有一定的治疗价值。同时，与当前的治疗药物相结合，可能效果还有叠加作用。, objectTitle=Nature子刊：雷帕霉素治疗肌萎缩侧索硬化症的随机、双盲、安慰剂对照试验, objectType=article, longId=793618, objectId=1dcce93618a0, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20230925/1695633199273_2570354.jpg, objectUrl=/article/show_article.do?id=1dcce93618a0, replyNumber=0, likeNumber=215, createdTime=2023-09-26, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=加利福尼亚, moduleDTOList=[ModuleDTO(moduleId=1dcce93618a0, moduleTitle=Nature子刊：雷帕霉素治疗肌萎缩侧索硬化症的随机、双盲、安慰剂对照试验, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=1dcce93618a0)], followStatus=false, userIsMember=false, type=1, lengthMark=0), GetTopicListResponse(id=2148733, encodeId=faaf2148e3312, content=<a href='/topic/show?id=049b86109ff' target=_blank style='color:#2F92EE;'>#自噬#</a>阿霉素（Dox）化疗时左心室质量和恶病质调控通路的重要性，建议在临床上提高对热量摄入与化疗相关恶病质和心脏毒性之间关系的警惕, objectTitle=自噬, objectType=topic, longId=86109, objectId=null, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/Random/097.jpg, objectUrl=null, replyNumber=0, likeNumber=117, createdTime=2023-07-19, rootId=0, userName=ms2000000147841561, userId=5bf26472850, projectId=1, avatar=, status=1, hasArticle=0, attachment=null, ipAttribution=, moduleDTOList=null, followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

自噬的两面，让它永远是正面的

2020-05-29

侠胆医心 (审核中...)

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全文收起 #参附注射液#（SF）是由宋代中医古籍#《严氏济生方》#中记载的参附汤研制而成的中药复方制剂，由#人参#和#附子#两味中药组成。SF在中医中用于治疗#厥证#（与现代休克相对应），以其回阳、益气、救脱的作用而闻名。SF对脊髓、脑、小肠、肾脏和心脏等器官的失血性休克和I/R损伤引起的多器官#再灌注损伤#具有保护作用。肝#缺血再灌注损伤#（HIRI）是外科手术后不可避免的挑战。肝脏中#活性氧#（ROS）的积累，沿着#缺血/再灌注#（I/R）引发的炎症反应，启动一系列有害的先天免疫反应，导致肝细胞死亡、#自噬#、循环障碍、能量代谢失调和#氧化应激#。这些反应最终导致急性或慢性排斥反应，并可能导致#肝衰竭#。

J Ethnopharmacol：参附注射液通过JAK2/STAT3途径诱导铁死亡改善肝脏缺血再灌注损伤

2025-05-06发表于威斯康星

梅斯管理员 (审核中...)

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#自噬# #睾丸#

干货！睾丸主要细胞的自噬及其研究进展

2025-03-20发表于陕西省

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#临床试验# #IL-6# #自噬# #桂枝茯苓胶囊# #网络药理学分析# #硼替佐米诱导的周围神经病变#

Phytomedicine：桂枝茯苓胶囊可通过降低白细胞介素-6水平调节mTOR通路诱导的自噬来缓解硼替佐米所致的周围神经病变

2025-02-28发表于陕西省

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#阿尔茨海默病# #自噬# #细胞焦亡# #郁金# #PINK1/Parkin通路#

Phytomedicine：郁金提取物通过PINK1/Parkin介导的自噬减轻阿尔茨海默病的认知缺陷，抑制焦亡

2025-02-17发表于陕西省

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#衰老# #自噬#

Nature Aging：为何男性衰老更快？分子伴侣介导自噬（CMA）的性别特异性解析

2025-02-11发表于陕西省

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#细胞凋亡# #自噬# #肿瘤坏死因子# #溃疡性结肠炎# #肠屏障# #加减交气散#

Phytomedicine：加减交气散增强慢性溃疡性结肠炎上皮细胞自噬，抑制TNF触发的细胞凋亡

2024-12-15发表于上海

梅斯管理员 (审核中...)

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#肝细胞癌# #细胞凋亡# #自噬# #中医药# #消癌解毒方#

J Ethnopharmacol：消癌解毒方通过AKT/mTOR通路刺激肝癌细胞自噬，降低肝癌细胞存活，诱导凋亡

2024-11-28

梅斯管理员 (审核中...)

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#细胞凋亡# #自噬# #肝损伤# #斑蝥素# #DDIT4#

Front Pharmacol：DDIT4/mTOR信号通路介导斑蝥素诱导的肝毒性和细胞损伤

2024-11-21发表于陕西省

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#自噬# #黄芪# #当归# #细胞焦亡# #脑缺血/再灌注损伤# #AMPK/mTOR通路#

J Ethnopharmacol：黄芪-当归药对通过AMPK/mTOR信号通路促进大鼠大脑中动脉闭塞/再灌注后的自噬活性减轻焦亡

2024-10-29发表于上海

梅斯管理员 (审核中...)

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#胶质瘤# #自噬# #云南白药# #坏死性凋亡#

J Ethnopharmacol：云南白药通过诱导自噬依赖性坏死性凋亡发挥抗胶质瘤活性

2024-08-07发表于上海

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#胰腺炎# #自噬#

eGastroenterology：自噬在胰腺炎中的作用

2024-05-31发表于上海

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#骨髓间充质干细胞# #树突状细胞# #自噬# #外泌体# #呼吸道合胞病毒#

J Ethnopharmacol：五虎汤对RSV诱导外泌体处理树突状细胞功能和自噬的影响

2024-05-30发表于上海

梅斯管理员 (审核中...)

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#自噬# #慢性阻塞性肺病# #气道上皮屏障# #补肺益肾方# #SIRT1/AMPK/FOXO3信号#

Chin Med：补肺益肾方通过Sirt1/AMPK/Foxo3信号通路增强自噬，保护气道上皮屏障，改善COPD

2024-02-29发表于上海

梅斯管理员 (审核中...)

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#肝衰竭# #自噬#

特别关注｜自噬对肝衰竭的保护作用机制与临床价值

2024-02-07发表于陕西省

ms2000000147841561 (审核中...)

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#自噬# 谢谢老师！

2024-01-02发表于河北省

梅斯管理员 (审核中...)

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#衰老# #自噬# #中医药# #六味地黄丸# #绝经后骨质疏松症(PMOP)# #Yes相关蛋白(YAP)#

Pharm Biol：六味地黄丸通过YAP-自噬轴延缓骨髓间充质干细胞(BMSC)衰老，减轻卵巢切除所致骨质流失

2023-12-21发表于上海

ms2000000147841561 (审核中...)

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#自噬# 喝点牛奶洗面奶

2023-11-23发表于河北省

ms2000000147841561 (审核中...)

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#自噬# 好记性不如烂笔头

2023-10-22发表于河北省

侠胆医心 (审核中...)

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#雷帕霉素#治疗#肌萎缩侧索硬化症#，雷帕霉素作为#自噬#诱导剂，原则上对所有的#退行性病变#都有一定的治疗价值。同时，与当前的治疗药物相结合，可能效果还有叠加作用。

Nature子刊：雷帕霉素治疗肌萎缩侧索硬化症的随机、双盲、安慰剂对照试验

2023-09-26发表于加利福尼亚

ms2000000147841561 (审核中...)

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#自噬#阿霉素（Dox）化疗时左心室质量和恶病质调控通路的重要性，建议在临床上提高对热量摄入与化疗相关恶病质和心脏毒性之间关系的警惕

2023-07-19

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