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href='/topic/show?id=0de5290588c' target=_blank style='color:#2F92EE;'>#免疫检查点抑制剂#</a>, objectTitle=单用PD-1最长生存期5年以上，KRAS和TP53两个基因共突变患者的专属幸运符！, objectType=article, longId=804487, objectId=b6b380448e6f, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/20221120/1669014277918_4754896.webp, objectUrl=/article/show_article.do?id=b6b380448e6f, replyNumber=0, likeNumber=151, createdTime=2023-12-19, rootId=0, userName=梅斯管理员, userId=cade5395722, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=b6b380448e6f, moduleTitle=单用PD-1最长生存期5年以上，KRAS和TP53两个基因共突变患者的专属幸运符！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=b6b380448e6f)], followStatus=false, userIsMember=false, type=null, lengthMark=0), GetTopicListResponse(id=2160818, encodeId=2fa1216081852, content=<a href='/topic/show?id=cb4e106e2696' target=_blank style='color:#2F92EE;'>#丹酚酸#</a>F(SalF)(<a href='/topic/show?id=6054106e2761' target=_blank style='color:#2F92EE;'>#Salvianolic acid#</a>)是中药<a href='/topic/show?id=5eb12311579' target=_blank style='color:#2F92EE;'>#丹参#</a>的衍生单体，与<a href='/topic/show?id=13cb1056e20' target=_blank style='color:#2F92EE;'>#KRAS#</a>具有较高的结合亲和力，尤其是对<a href='/topic/show?id=60d3106e28e1' target=_blank style='color:#2F92EE;'>#KRAS G12D#</a>的结合亲和力。这是极有意思的研究。当然丹酚酸对KRAS G12D亲和力肯定是不高的，但是这些弱的亲和力，能否增强其它KRAS G12D的抑制剂的作用，这是令人感兴趣的。另外，丹酚酸今后还可以通过进一步化学改造，变成KRAS的多突变的抑制剂，也是有可能的。还有，其它中药，是否有类似的作用？如<a href='/topic/show?id=adcc450048e' target=_blank style='color:#2F92EE;'>#姜黄素#</a>，<a href='/topic/show?id=da54104e108d' target=_blank style='color:#2F92EE;'>#三七皂苷#</a>是否有类似作用？, objectTitle=Phytomedicine：丹酚酸F通过PI3K/AKT信号通路抑制KRAS依赖性肺癌细胞的生长, objectType=article, longId=794523, objectId=3af5e9452355, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/202301003/1696313387146_5610093.jpg, objectUrl=/article/show_article.do?id=3af5e9452355, replyNumber=0, likeNumber=174, createdTime=2023-10-04, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=3af5e9452355, moduleTitle=Phytomedicine：丹酚酸F通过PI3K/AKT信号通路抑制KRAS依赖性肺癌细胞的生长, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=3af5e9452355)], followStatus=false, userIsMember=false, type=1, lengthMark=1), GetTopicListResponse(id=2123427, encodeId=bfc6212342e19, content=新一款<a href='/topic/show?id=13cb1056e20' target=_blank style='color:#2F92EE;'>#KRAS#</a>基因靶向药<a href='/topic/show?id=5bf6105e4617' target=_blank style='color:#2F92EE;'>#garsorasib#</a>，对<a href='/topic/show?id=2493130e1a1' target=_blank style='color:#2F92EE;'>#NSCLC#</a>的<a href='/topic/show?id=1438105e47a1' target=_blank style='color:#2F92EE;'>#KRAS G12C突变#</a>患者疾病控制率高达90%！, objectTitle=新一款KRAS基因靶向药garsorasib，对NSCLC的KRAS G12C突变患者疾病控制率高达90%！, objectType=article, longId=765344, objectId=a4f9e65344f5, topicUrl=null, isHasObj=0, objectCover=https://img.medsci.cn/images/20230313/6e183a0e504b4009b3ba4647a836382d.jpg, objectUrl=/article/show_article.do?id=a4f9e65344f5, replyNumber=0, likeNumber=176, createdTime=2023-04-03, rootId=0, userName=侠胆医心, userId=f63e4754896, projectId=1, avatar=, status=1, hasArticle=1, attachment=null, ipAttribution=上海, moduleDTOList=[ModuleDTO(moduleId=a4f9e65344f5, moduleTitle=新一款KRAS基因靶向药garsorasib，对NSCLC的KRAS G12C突变患者疾病控制率高达90%！, moduleType=article, hrefUrl=https://www.medsci.cn/article/show_article.do?id=a4f9e65344f5)], followStatus=false, userIsMember=false, type=1, lengthMark=0)] 梅斯话题小助手

KRAS

2020-05-29

梅斯管理员 (审核中...)

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#KRAS# #MYC# #siRNAs#

2025-08-05发表于上海

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#结直肠癌# #突变# #KRAS#

2025-05-06发表于上海

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#胰腺癌# #KRAS# #PIKfyve# #MAPK#

2025-04-27发表于上海

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#非小细胞肺癌# #KRAS#

绘真约大咖 | 姜丽教授：多角度了解非小细胞肺癌的新晋“明星”靶点KRAS

2024-12-18发表于陕西省

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#造血干细胞# #KRAS# #TRA2β#

2024-09-26发表于上海

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#KRAS# #PROTAC# #蛋白降解剂# # ACBI3 #

2024-09-24发表于上海

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#非小细胞肺癌# #KRAS#

KRAS G12C突变非小细胞肺癌患者的临床、病理和分子特征

2024-09-21发表于上海

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#非小细胞肺癌# #KRAS#

抗癌新药IBI351疗效数据出炉，近50%的KRAS基因突变患者病灶缩小30%！

2024-09-12发表于上海

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#KRAS# #RAS通路#

RAS癌症靶向治疗的药物开发

2024-08-26发表于上海

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#胰腺导管腺癌# #KRAS# #分子残留疾病#

担心胰腺癌术后“卷土重来”，肿瘤知情ctDNA-MRD针对I-III期患者均能预测复发风险

2024-08-18发表于上海

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#胰腺癌# #KRAS#

Nat Commun：中南大学金鑫/华中科技大学江科/唐露发现KRAS加速胰腺癌进展的新机制

2024-06-03发表于上海

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#结肠癌# #胰腺癌# #CRC# #KRAS# #PDAC#

读书报告 | AMPLIFY-201研究：淋巴结靶向性KRAS疫苗治疗胰腺癌和结肠癌的I期临床研究

2024-04-26发表于陕西省

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#肺癌# #KRAS# #LKB1# #STK11#

KRAS突变的肿瘤预后如何？STK11/LKB1基因会来捣乱缩短生存期！

2024-03-02发表于上海

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#KRAS# #TP53# #高级别浆液性卵巢癌#

基因检测检出KRAS/TP53共突变，识破高级别浆液性卵巢癌的“低级别”伪装

2024-02-23发表于上海

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#胰腺癌# #KRAS# #KRAS抑制剂#

KRAS突变抑制剂最新汇总与对比：肺癌，胰腺癌，结直肠癌......

2024-01-14发表于加利福尼亚

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#KRAS# #深度突变扫描# #变构位点#

2023-12-27发表于上海

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#结直肠癌# #KRAS# #代谢组学# #球状体# #PFAS#

2023-12-22发表于上海

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#KRAS# #TP53# #免疫检查点抑制剂#

单用PD-1最长生存期5年以上，KRAS和TP53两个基因共突变患者的专属幸运符！

2023-12-19发表于上海

侠胆医心 (审核中...)

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全文收起 #丹酚酸#F(SalF)(#Salvianolic acid#)是中药#丹参#的衍生单体，与#KRAS#具有较高的结合亲和力，尤其是对#KRAS G12D#的结合亲和力。这是极有意思的研究。当然丹酚酸对KRAS G12D亲和力肯定是不高的，但是这些弱的亲和力，能否增强其它KRAS G12D的抑制剂的作用，这是令人感兴趣的。另外，丹酚酸今后还可以通过进一步化学改造，变成KRAS的多突变的抑制剂，也是有可能的。还有，其它中药，是否有类似的作用？如#姜黄素#，#三七皂苷#是否有类似作用？

Phytomedicine：丹酚酸F通过PI3K/AKT信号通路抑制KRAS依赖性肺癌细胞的生长

2023-10-04发表于上海

侠胆医心 (审核中...)

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新一款#KRAS#基因靶向药#garsorasib#，对#NSCLC#的#KRAS G12C突变#患者疾病控制率高达90%！

新一款KRAS基因靶向药garsorasib，对NSCLC的KRAS G12C突变患者疾病控制率高达90%！

2023-04-03发表于上海

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