osimertinib-话题@MedSci

#osimertinib#

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osimertinib

2020-05-29

梅斯管理员 (审核中...)

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#非小细胞肺癌# #osimertinib#

CA Cancer J Clin：EGFR突变非小细胞肺癌——从早期到晚期疾病的个性化管理新进展

2025-07-19发表于上海

yangchou (审核中...)

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全文收起 #osimertinib# EGFR基因的激活性突变，尤其是19号外显子缺失（Ex19del）及21号外显子L858R点突变在NSCLC患者中占多数，约85%-90%。三代EGFR-TKI如osimertinib及lazertinib已被证实优于早期一代药物，提高PFS和安全性。Osimertinib是全球广泛应用的标准治疗，但伴随心脏毒性等安全问题的报道逐渐增多。Lazertinib是一款高选择性且有效通过血脑屏障的三代EGFR-TKI，对野生型EGFR毒性相对较低，尤其对心脏QT间期延长的影响较小，理论基础更稳固。

2025-07-14发表于浙江省

梅斯管理员 (审核中...)

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#osimertinib# #lazertinib# #EGFR突变晚期非小细胞肺癌#

Lazertinib Vs Osimertinib：MARIPOSA研究探索EGFR突变晚期非小细胞肺癌初治患者的疗效和安全性比较

2025-07-14发表于上海

梅斯管理员 (审核中...)

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#NSCLC# #osimertinib# #lazertinib# #amivantamab# #WCLC 2024#

WCLC 2024 ：Amivantamab联合Lazertinib对比Osimertinib一线治疗EGFR突变NSCLC展现更优疗效（MARIPOSA研究）

2024-09-03发表于上海

dongjia2012 (审核中...)

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#osimertinib#

Ann Oncol：二线Osimertinib（奥希替尼）联合贝伐珠单抗并不能明显改善EGFR突变晚期NSCLC获得T790M突变患者的预后

2022-02-11

dongjia2012 (审核中...)

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#osimertinib#

JCO：BLOOM研究——Osimertinib在EGFRm和LM非小细胞肺癌患者中的应用

2020-12-18

dongjia2012 (审核中...)

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#osimertinib#

阿斯利康的EGFR抑制剂osimertinib辅助治疗非小细胞肺癌，获得FDA优先审查

2020-10-22

dongjia2012 (审核中...)

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#osimertinib#

抑癌基因疗法Oncoprex与Osimertinib联合治疗非小细胞肺癌（NSCLC）

2020-02-08

dongjia2012 (审核中...)

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#osimertinib#

NEJM：Osimertinib一线治疗晚期非小细胞肺癌

2020-01-10

dongjia2012 (审核中...)

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#osimertinib#

J Clin Oncol：Osimertinib用于携带EGFR罕见突变NSCLC患者的疗效和安全性

2020-01-07

dongjia2012 (审核中...)

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#osimertinib#

NMPA授予Tagrisso（osimertinib）上市许可，治疗EGFR突变的非小细胞肺癌

2019-09-07

dongjia2012 (审核中...)

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#osimertinib#

CLIN CANCER RES：Osimertinib治疗EGFR突变非小细胞肺癌的耐药机制

2018-12-23

dongjia2012 (审核中...)

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#osimertinib#

JCO：晚期非小细胞肺癌患者Osimertinib或EGFR-TKI治疗的中枢神经系统反应

2018-08-31

dongjia2012 (审核中...)

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#osimertinib#

CLIN CANCER RES：非小细胞肺癌患者Osimertinib耐药机制

2018-07-07

dongjia2012 (审核中...)

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#osimertinib#

JCO：Osimertinib比化疗有利于改善晚期非小细胞肺癌患者的状态

2018-05-14

dongjia2012 (审核中...)

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#osimertinib#

EUR J Cancer：需对Osimertinib诱导的QT延长严加防范

2018-02-28

dongjia2012 (审核中...)

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#osimertinib#

欧洲药品管理局已经接受了Tagrisso（osimertinib）营销授权申请

2017-12-03

dongjia2012 (审核中...)

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#osimertinib#

[重磅]第三代TKI药物甲磺酸奥希替尼（AZD9291, Osimertinib）于中国快速获批

2017-03-27

dongjia2012 (审核中...)

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#osimertinib#

2016NICE技术评估指南：osimertinib用于治疗局部晚期或转移性EGFR T790M突变阳性非小细胞肺癌（TA416）发布

2016-10-28

dongjia2012 (审核中...)

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#osimertinib#

第三代肺癌EGFR-TKI药物osimertinib 3期临床获得成功

2016-07-21

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