加拿大卡尔加里大学公共卫生科学系的Kirsten M. Fiest等人2012年11月21日发表在Neurology杂志上的一项研究结果表明：癫痫患者（PWE）与抑郁症显著相关，癫痫患者中抑郁症发生率很高，应注意诊断及治疗癫痫患者的抑郁症。
研究人员检索了MEDLINE(1948–2012)、EMBASE(1980–2012)和PsycINFO(1806–2012) 的数据库、检索文章的参考文献目录、会议摘要。同时咨询了内容专家，由两个独立的资料收集人员分别筛查摘要并提取数据，纳入关于癫痫和抑郁症的人群为基础的研究、原始研究和报道。系统回顾和meta分析评估PWE中抑郁症的发生率，癫痫和抑郁症的相关性（根据报道的比值比OR）。
该研究发现：癫痫与抑郁症显著相关，癫痫患者中抑郁症发生率很高。这些结果突出了及时诊断和治疗癫痫患者发生抑郁症的重要性。
Objective
To estimate the prevalence of depression in persons with epilepsy (PWE) and the strength of association between these 2 conditions.
Methods
The MEDLINE (1948–2012), EMBASE (1980–2012), and PsycINFO (1806–2012) databases, reference lists of retrieved articles, and conference abstracts were searched. Content experts were also consulted. Two independent reviewers screened abstracts and extracted data. For inclusion, studies were population-based, original research, and reported on epilepsy and depression. Estimates of depression prevalence among PWE and of the association between epilepsy and depression (estimated with reported odds ratios [ORs]) are provided.
Results
Of 7,106 abstracts screened, 23 articles reported on 14 unique data sources. Nine studies reported on 29,891 PWE who had an overall prevalence of active (current or past-year) depression of 23.1% (95% confidence interval [CI] 20.6%–28.31%). Five of the 14 studies reported on 1,217,024 participants with an overall OR of active depression of 2.77 (95% CI 2.09–3.67) in PWE. For lifetime depression, 4 studies reported on 5,454 PWE, with an overall prevalence of 13.0% (95% CI 5.1–33.1), and 3 studies reported on 4,195 participants with an overall OR of 2.20 (95% CI 1.07–4.51) for PWE.
Conclusions
Epilepsy was significantly associated with depression and depression was observed to be highly prevalent in PWE. These findings highlight the importance of proper identification and management of depression in PWE.
与癫痫相关的拓展阅读：
来源：Neurology
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